Aspergillosis

AB1_ASPERGILLOSIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B44
  • Hospital discharge: ICD-9 1173
  • Hospital discharge: ICD-8 1173
  • Cause of death: ICD-10 B44
  • Cause of death: ICD-9 1173
  • Cause of death: ICD-8 1173

2 out of 7 registries used, show all original rules.

243

4. Check minimum number of events

None

243

5. Include endpoints

None

243

6. Filter based on genotype QC (FinnGen only)

230

Control definitions (FinnGen only)

Control exclude AB1_MYCOSES

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1897 694 1166
Only index persons 1320 508 812
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.03 0.02 0.03
Median age at first event (years)
Whole population 62.18 61.22 62.71
Only index persons 62.61 60.94 63.65

-FinnGen-

Key figures

All Female Male
Number of individuals 230 83 147
Unadjusted period prevalence (%) 0.06 0.03 0.07
Median age at first event (years) 62.43 58.06 64.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint AB1_ASPERGILLOSIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_ASPERGILLOSIS 4.089 [3.03, 5.52] < 0.001
Birth year 0.994 [0.99, 1.0] 0.199

During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 432 females with AB1_ASPERGILLOSIS died.

Males

Parameter HR [95% CI] p-value
AB1_ASPERGILLOSIS 5.317 [4.05, 6.99] < 0.001
Birth year 0.988 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 377 out of 732 males with AB1_ASPERGILLOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_ASPERGILLOSIS.

N-year risk Females Males
1 0.413% 0.945%
5 2.448% 6.264%
10 6.095% 14.861%
15 11.683% 27.194%
20 19.595% 41.719%

Relationships between endpoints

Index endpoint: AB1_ASPERGILLOSIS – Aspergillosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data