No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
10517 |
4. Check minimum number of eventsNone |
10517 |
5. Include endpoints |
10517 |
6. Filter based on genotype QC (FinnGen only) |
10124 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Mycoses
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 83406 | 44672 | 38126 |
| Only index persons | 72873 | 39767 | 33106 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.18 | 1.28 | 1.07 |
| Only index persons | 1.37 | 1.46 | 1.26 |
| Median age at first event (years) | |||
| Whole population | 49.47 | 47.02 | 52.29 |
| Only index persons | 48.19 | 45.55 | 51.37 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10124 | 5589 | 4535 |
| Unadjusted period prevalence (%) | 2.23 | 2.20 | 2.28 |
| Median age at first event (years) | 52.62 | 47.48 | 58.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AB1_MYCOSES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MYCOSES | 1.941 [1.76, 2.14] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.396 |
During the follow-up period (1.1.1998 — 31.12.2019), 5722 out of 31663 females with AB1_MYCOSES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MYCOSES | 2.072 [1.87, 2.29] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 6711 out of 26376 males with AB1_MYCOSES died.
Mortality risk
Mortality risk for people of age
years, who have AB1_MYCOSES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.169% | 0.407% |
| 5 | 1.149% | 2.217% |
| 10 | 2.984% | 5.655% |
| 15 | 5.837% | 10.394% |
| 20 | 9.957% | 16.525% |
Relationships between endpoints
↥Index endpoint: AB1_MYCOSES – Mycoses
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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