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Dermatophytosis

EFO Endpoint Browser PheWeb

AB1_DERMATOPHYTOSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B35
  • Hospital discharge: ICD-9 — 110
  • Hospital discharge: ICD-8 — 110
  • Cause of death: ICD-10 — B35
  • Cause of death: ICD-9 — 110
  • Cause of death: ICD-8 — 110

2 out of 7 registries used, show all original rules.

4649

4. Check minimum number of events

None

4649

5. Include endpoints

None

4649

6. Filter based on genotype QC (FinnGen only)

4510

Control definitions (FinnGen only)

Control exclude AB1_MYCOSES

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 36369 15440 20714
Only index persons 32219 13723 18496
Unadjusted period prevalence (%)
Whole population 0.52 0.44 0.58
Only index persons 0.62 0.50 0.71
Median age at first event (years)
Whole population 54.08 55.94 52.65
Only index persons 53.56 55.39 52.20

-FinnGen-

Key figures

All Female Male
Number of individuals 4510 1908 2602
Unadjusted period prevalence (%) 1.07 0.75 1.31
Median age at first event (years) 57.18 55.12 58.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_DERMATOPHYTOSIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_DERMATOPHYTOSIS 1.662 [1.49, 1.85] < 0.001
Birth year 0.988 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 2070 out of 10637 females with AB1_DERMATOPHYTOSIS died.

Males

Parameter HR [95% CI] p-value
AB1_DERMATOPHYTOSIS 1.583 [1.43, 1.75] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 3119 out of 13738 males with AB1_DERMATOPHYTOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_DERMATOPHYTOSIS.

N-year risk Females Males
1 0.116% 0.267%
5 0.782% 1.751%
10 1.971% 4.39%
15 3.475% 8.116%
20 6.162% 13.442%

Relationships between endpoints

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Index endpoint: AB1_DERMATOPHYTOSIS – Dermatophytosis

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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