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Candidiasis

EFO Endpoint Browser PheWeb

AB1_CANDIDIASIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B37
  • Hospital discharge: ICD-9 — 112
  • Hospital discharge: ICD-8 — 112
  • Cause of death: ICD-10 — B37
  • Cause of death: ICD-9 — 112
  • Cause of death: ICD-8 — 112

2 out of 7 registries used, show all original rules.

4982

4. Check minimum number of events

None

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5. Include endpoints

None

4982

6. Filter based on genotype QC (FinnGen only)

4769

Control definitions (FinnGen only)

Control exclude AB1_MYCOSES

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 38361 25371 12707
Only index persons 33606 22803 10803
Unadjusted period prevalence (%)
Whole population 0.60 0.73 0.36
Only index persons 0.70 0.84 0.41
Median age at first event (years)
Whole population 43.09 37.41 54.38
Only index persons 41.76 36.25 53.38

-FinnGen-

Key figures

All Female Male
Number of individuals 4769 3291 1478
Unadjusted period prevalence (%) 1.12 1.29 0.74
Median age at first event (years) 46.55 40.09 60.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_CANDIDIASIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_CANDIDIASIS 2.209 [1.96, 2.49] < 0.001
Birth year 0.995 [0.99, 1.0] 0.243

During the follow-up period (1.1.1998 — 31.12.2019), 3272 out of 18717 females with AB1_CANDIDIASIS died.

Males

Parameter HR [95% CI] p-value
AB1_CANDIDIASIS 2.783 [2.44, 3.17] < 0.001
Birth year 0.989 [0.98, 1.0] 0.028

During the follow-up period (1.1.1998 — 31.12.2019), 2863 out of 9856 males with AB1_CANDIDIASIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_CANDIDIASIS.

N-year risk Females Males
1 0.173% 0.462%
5 1.476% 3.097%
10 3.09% 8.088%
15 6.23% 15.566%
20 11.174% 25.078%

Relationships between endpoints

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Index endpoint: AB1_CANDIDIASIS – Candidiasis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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