Asthma mixed form (mode)

ASTHMA_MIXED_EXMORE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Check mode of ICD-10 codes: %J458

Registry filters:

  • Hospital discharge: ICD-10 J45.8
  • Cause of death: ICD-10 J45.8

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 25457 12665 12623
Only index persons 21583 11039 10544
Unadjusted period prevalence (%)
Whole population 0.36 0.36 0.35
Only index persons 0.40 0.41 0.40
Median age at first event (years)
Whole population 40.31 48.39 31.78
Only index persons 36.53 46.30 26.30

-FinnGen-

Key figures

All Female Male
Number of individuals 2155 1256 899
Unadjusted period prevalence (%) 0.48 0.49 0.45
Median age at first event (years) 53.36 48.34 60.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint ASTHMA_MIXED_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
ASTHMA_MIXED_EXMORE 1.854 [1.7, 2.02] < 0.001
Birth year 0.996 [0.99, 1.0] 0.331

During the follow-up period (1.1.1998 — 31.12.2019), 2432 out of 11328 females with ASTHMA_MIXED_EXMORE died.

Males

Parameter HR [95% CI] p-value
ASTHMA_MIXED_EXMORE 1.806 [1.64, 1.98] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 2457 out of 11523 males with ASTHMA_MIXED_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have ASTHMA_MIXED_EXMORE.

N-year risk Females Males
1 0.163% 0.312%
5 1.025% 1.98%
10 2.663% 4.947%
15 5.052% 9.244%
20 9.006% 15.523%

Relationships between endpoints

Index endpoint: ASTHMA_MIXED_EXMORE – Asthma mixed form (mode)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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