No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersCheck mode of ICD-10 codes: %J458 Registry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
J10_ASTHMA, ALLERG_ASTHMA, VOCALCORDDYS, I9_HEARTFAIL, J10_HYPERSPNEUMONI, ASTHMA_EXCL
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Asthma mixed form (mode)
based on the number of shared cases.
Similar with more cases:
- Asthma mixed form (mode)
- Asthma (diagnoses ohter than nonallergic)
- Asthma
- Asthma
- Asthma, including avohilmo
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 25457 | 12665 | 12623 |
| Only index persons | 21583 | 11039 | 10544 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.36 | 0.36 | 0.35 |
| Only index persons | 0.40 | 0.41 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 40.31 | 48.39 | 31.78 |
| Only index persons | 36.53 | 46.30 | 26.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2155 | 1256 | 899 |
| Unadjusted period prevalence (%) | 0.48 | 0.49 | 0.45 |
| Median age at first event (years) | 53.36 | 48.34 | 60.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ASTHMA_MIXED_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_MIXED_EXMORE | 1.854 [1.7, 2.02] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.331 |
During the follow-up period (1.1.1998 — 31.12.2019), 2432 out of 11328 females with ASTHMA_MIXED_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ASTHMA_MIXED_EXMORE | 1.806 [1.64, 1.98] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 2457 out of 11523 males with ASTHMA_MIXED_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have ASTHMA_MIXED_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.163% | 0.312% |
| 5 | 1.025% | 1.98% |
| 10 | 2.663% | 4.947% |
| 15 | 5.052% | 9.244% |
| 20 | 9.006% | 15.523% |
Relationships between endpoints
↥Index endpoint: ASTHMA_MIXED_EXMORE – Asthma mixed form (mode)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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