No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to
Alzheimer’s disease (Atypical or mixed)
based on the number of shared cases.
Similar with more cases:
- Alzheimer’s disease (Atypical or mixed)
- Alzheimer’s disease, wide definition
- Alzheimer’s disease, wide definition
- Any dementia
- Any dementia
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 49324 | 30174 | 18896 |
Only index persons | 44818 | 27767 | 17051 |
Unadjusted period prevalence (%) | |||
Whole population | 0.73 | 0.86 | 0.53 |
Only index persons | 0.88 | 1.02 | 0.65 |
Median age at first event (years) | |||
Whole population | 83.60 | 84.60 | 82.06 |
Only index persons | 83.87 | 84.83 | 82.31 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 2700 | 1120 | 1580 |
Unadjusted period prevalence (%) | 0.65 | 0.44 | 0.79 |
Median age at first event (years) | 81.38 | 81.83 | 81.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AD_AM_EXMORE and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
AD_AM_EXMORE | 2.457 [2.15, 2.8] | < 0.001 |
Birth year | 0.994 [0.99, 1.0] | 0.115 |
During the follow-up period (1.1.1998 — 31.12.2019), 14195 out of 22026 females with AD_AM_EXMORE died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
AD_AM_EXMORE | 2.861 [2.4, 3.41] | < 0.001 |
Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 9194 out of 13609 males with AD_AM_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have AD_AM_EXMORE.N-year risk | Females | Males |
---|---|---|
1 | 0.236% | 0.516% |
5 | 1.387% | 2.993% |
10 | 3.512% | 7.569% |
15 | 6.285% | 14.062% |
20 | 10.835% | 22.816% |
Relationships between endpoints
↥Index endpoint: AD_AM_EXMORE – Alzheimer’s disease (Atypical or mixed)
GWS hits: 4