Alzheimer’s disease (Atypical or mixed)

AD_AM_EXMORE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 49324 30174 18896
Only index persons 44818 27767 17051
Unadjusted period prevalence (%)
Whole population 0.73 0.86 0.53
Only index persons 0.88 1.02 0.65
Median age at first event (years)
Whole population 83.60 84.60 82.06
Only index persons 83.87 84.83 82.31

-FinnGen-

Key figures

All Female Male
Number of individuals 2700 1120 1580
Unadjusted period prevalence (%) 0.65 0.44 0.79
Median age at first event (years) 81.38 81.83 81.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AD_AM_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
AD_AM_EXMORE 2.457 [2.15, 2.8] < 0.001
Birth year 0.994 [0.99, 1.0] 0.115

During the follow-up period (1.1.1998 — 31.12.2019), 14195 out of 22026 females with AD_AM_EXMORE died.

Males

Parameter HR [95% CI] p-value
AD_AM_EXMORE 2.861 [2.4, 3.41] < 0.001
Birth year 0.987 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 9194 out of 13609 males with AD_AM_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have AD_AM_EXMORE.

N-year risk Females Males
1 0.236% 0.516%
5 1.387% 2.993%
10 3.512% 7.569%
15 6.285% 14.062%
20 10.835% 22.816%

Relationships between endpoints

Index endpoint: AD_AM_EXMORE – Alzheimer’s disease (Atypical or mixed)

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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