Infections with a predominantly sexual mode of transmission

AB1_SEXUAL_TRANSMISSION

tabes dorsalis: A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A50-A64
  • Hospital discharge: ICD-9 09[0-9]|0541|131|0781C
  • Hospital discharge: ICD-8 09[0-9]|131
  • Cause of death: ICD-10 A50-A64
  • Cause of death: ICD-9 09[0-9]|0541|131|0781C
  • Cause of death: ICD-8 09[0-9]|131

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

14024

6. Filter based on genotype QC (FinnGen only)

13366

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 123298 78020 44342
Only index persons 117330 75050 42280
Unadjusted period prevalence (%)
Whole population 1.87 2.23 1.24
Only index persons 2.35 2.76 1.61
Median age at first event (years)
Whole population 26.14 25.54 27.09
Only index persons 25.93 25.40 26.88

-FinnGen-

Key figures

All Female Male
Number of individuals 13366 9896 3470
Unadjusted period prevalence (%) 3.33 3.89 1.74
Median age at first event (years) 27.90 26.59 31.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_SEXUAL_TRANSMISSION and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SEXUAL_TRANSMISSION 1.405 [1.25, 1.57] < 0.001
Birth year 0.998 [0.99, 1.01] 0.564

During the follow-up period (1.1.1998 — 31.12.2019), 1846 out of 56798 females with AB1_SEXUAL_TRANSMISSION died.

Males

Parameter HR [95% CI] p-value
AB1_SEXUAL_TRANSMISSION 1.37 [1.23, 1.53] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1639 out of 35162 males with AB1_SEXUAL_TRANSMISSION died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SEXUAL_TRANSMISSION.

N-year risk Females Males
1 0.172% 0.261%
5 0.918% 1.542%
10 2.386% 3.806%
15 4.36% 7.169%
20 7.621% 11.992%

Relationships between endpoints

Index endpoint: AB1_SEXUAL_TRANSMISSION – Infections with a predominantly sexual mode of transmission

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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