Syphilis

AB1_SYPHILIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

831

6. Filter based on genotype QC (FinnGen only)

766

Control definitions (FinnGen only)

Control exclude AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6496 2541 3811
Only index persons 5450 2193 3257
Unadjusted period prevalence (%)
Whole population 0.09 0.07 0.11
Only index persons 0.11 0.08 0.12
Median age at first event (years)
Whole population 46.90 46.69 47.41
Only index persons 45.30 44.04 46.15

-FinnGen-

Key figures

All Female Male
Number of individuals 766 258 508
Unadjusted period prevalence (%) 0.20 0.10 0.26
Median age at first event (years) 47.14 45.62 47.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_SYPHILIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SYPHILIS 2.438 [2.02, 2.94] < 0.001
Birth year 0.998 [0.99, 1.01] 0.586

During the follow-up period (1.1.1998 — 31.12.2019), 373 out of 1614 females with AB1_SYPHILIS died.

Males

Parameter HR [95% CI] p-value
AB1_SYPHILIS 2.499 [2.1, 2.98] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 561 out of 2476 males with AB1_SYPHILIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SYPHILIS.

N-year risk Females Males
1 0.115% 0.567%
5 1.038% 3.026%
10 3.365% 7.243%
15 6.756% 13.391%
20 12.396% 22.162%

Relationships between endpoints

Index endpoint: AB1_SYPHILIS – Syphilis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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