≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Anogenital herpesviral [herpes simplex] infection

EFO Endpoint Browser PheWeb

AB1_ANOGENITAL_HERPES_SIMPLEX

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A60
  • Hospital discharge: ICD-9 — 0541A
  • Hospital discharge: ICD-8 — 5402
  • Cause of death: ICD-10 — A60
  • Cause of death: ICD-9 — 0541A
  • Cause of death: ICD-8 — 5402

2 out of 7 registries used, show all original rules.

2351

4. Check minimum number of events

None

2351

5. Include endpoints

None

2351

6. Filter based on genotype QC (FinnGen only)

2236

Control definitions (FinnGen only)

Control exclude AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17791 11901 5755
Only index persons 17294 11677 5617
Unadjusted period prevalence (%)
Whole population 0.28 0.34 0.16
Only index persons 0.36 0.43 0.21
Median age at first event (years)
Whole population 29.31 27.62 32.76
Only index persons 29.21 27.59 32.58

-FinnGen-

Key figures

All Female Male
Number of individuals 2236 1701 535
Unadjusted period prevalence (%) 0.57 0.67 0.27
Median age at first event (years) 32.73 30.02 41.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_ANOGENITAL_HERPES_SIMPLEX and mortality.

Females

Parameter HR [95% CI] p-value
AB1_ANOGENITAL_HERPES_SIMPLEX 1.478 [1.24, 1.77] < 0.001
Birth year 0.999 [0.99, 1.01] 0.774

During the follow-up period (1.1.1998 — 31.12.2019), 245 out of 9937 females with AB1_ANOGENITAL_HERPES_SIMPLEX died.

Males

Parameter HR [95% CI] p-value
AB1_ANOGENITAL_HERPES_SIMPLEX 1.04 [0.89, 1.22] 0.631
Birth year 0.987 [0.98, 1.0] 0.023

During the follow-up period (1.1.1998 — 31.12.2019), 264 out of 5301 males with AB1_ANOGENITAL_HERPES_SIMPLEX died.

Mortality risk

Mortality risk for people of age

years, who have AB1_ANOGENITAL_HERPES_SIMPLEX.

N-year risk Females Males
1 0.155% 0.245%
5 1.036% 1.155%
10 2.609% 2.958%
15 4.978% 5.608%
20 8.779% 9.633%

Relationships between endpoints

↥

Index endpoint: AB1_ANOGENITAL_HERPES_SIMPLEX – Anogenital herpesviral [herpes simplex] infection

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data