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Gonococcal infection

DOID Endpoint Browser PheWeb

AB1_GONOCOCCAL

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A54
  • Hospital discharge: ICD-9 — 09[8]
  • Hospital discharge: ICD-8 — 09[8]
  • Cause of death: ICD-10 — A54
  • Cause of death: ICD-9 — 09[8]
  • Cause of death: ICD-8 — 09[8]

2 out of 7 registries used, show all original rules.

1120

4. Check minimum number of events

None

1120

5. Include endpoints

None

1120

6. Filter based on genotype QC (FinnGen only)

1054

Control definitions (FinnGen only)

Control exclude AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8919 6018 2796
Only index persons 8042 5459 2583
Unadjusted period prevalence (%)
Whole population 0.14 0.17 0.08
Only index persons 0.17 0.20 0.10
Median age at first event (years)
Whole population 25.79 23.82 29.81
Only index persons 25.63 23.67 29.77

-FinnGen-

Key figures

All Female Male
Number of individuals 1054 742 312
Unadjusted period prevalence (%) 0.25 0.29 0.16
Median age at first event (years) 26.11 22.89 33.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_GONOCOCCAL and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
AB1_GONOCOCCAL 1.311 [0.95, 1.82] 0.105
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 1743 males with AB1_GONOCOCCAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_GONOCOCCAL.

N-year risk Females Males
1 No data 0.233%
5 No data 1.354%
10 No data 3.354%
15 No data 6.516%
20 No data 10.785%

Relationships between endpoints

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Index endpoint: AB1_GONOCOCCAL – Gonococcal infection

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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