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Other predominantly sexually transmitted diseases, not elsewhere classified

EFO Endpoint Browser PheWeb

AB1_SEXUAL_TRANSMISSION_NOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A63, A64
  • Hospital discharge: ICD-9 — 09[9]
  • Hospital discharge: ICD-8 — 09[9]
  • Hospital discharge: excluded ICD-9 — 099[1-2]
  • Hospital discharge: excluded ICD-8 — 099[1-2]
  • Cause of death: ICD-10 — A63, A64
  • Cause of death: ICD-9 — 09[9]
  • Cause of death: ICD-8 — 09[9]
  • Cause of death: excluded ICD-9 — 099[1-2]
  • Cause of death: excluded ICD-8 — 099[1-2]

2 out of 7 registries used, show all original rules.

7356

4. Check minimum number of events

None

7356

5. Include endpoints

None

7356

6. Filter based on genotype QC (FinnGen only)

7060

Control definitions (FinnGen only)

Control exclude AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 63799 40334 23119
Only index persons 61623 39326 22297
Unadjusted period prevalence (%)
Whole population 0.97 1.16 0.65
Only index persons 1.23 1.45 0.85
Median age at first event (years)
Whole population 26.40 26.40 26.34
Only index persons 26.31 26.34 26.26

-FinnGen-

Key figures

All Female Male
Number of individuals 7060 5329 1731
Unadjusted period prevalence (%) 1.79 2.09 0.87
Median age at first event (years) 28.54 28.22 29.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_SEXUAL_TRANSMISSION_NOS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SEXUAL_TRANSMISSION_NOS 1.171 [1.04, 1.31] 0.007
Birth year 0.995 [0.99, 1.0] 0.206

During the follow-up period (1.1.1998 — 31.12.2019), 1162 out of 35084 females with AB1_SEXUAL_TRANSMISSION_NOS died.

Males

Parameter HR [95% CI] p-value
AB1_SEXUAL_TRANSMISSION_NOS 1.229 [1.08, 1.4] 0.002
Birth year 0.986 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 655 out of 19032 males with AB1_SEXUAL_TRANSMISSION_NOS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SEXUAL_TRANSMISSION_NOS.

N-year risk Females Males
1 0.094% 0.182%
5 0.651% 1.265%
10 1.574% 3.285%
15 2.974% 6.352%
20 5.503% 10.687%

Relationships between endpoints

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Index endpoint: AB1_SEXUAL_TRANSMISSION_NOS – Other predominantly sexually transmitted diseases, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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