No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1244 |
6. Filter based on genotype QC (FinnGen only) |
1198 |
Control definitions (FinnGen only)
Control exclude
AUTOIMMUNE
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
SLE (Finngen)
based on the number of shared cases.
Similar with more cases:
- Systemic lupus erythematosus
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
- Autoimmune diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8433 | 6670 | 1687 |
| Only index persons | 6978 | 5653 | 1325 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.19 | 0.05 |
| Only index persons | 0.18 | 0.21 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 50.68 | 49.61 | 54.71 |
| Only index persons | 48.57 | 47.43 | 53.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1198 | 991 | 207 |
| Unadjusted period prevalence (%) | 0.34 | 0.39 | 0.10 |
| Median age at first event (years) | 47.24 | 45.90 | 53.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint SLE_FG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLE_FG | 1.847 [1.66, 2.06] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 872 out of 4580 females with SLE_FG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLE_FG | 1.968 [1.64, 2.36] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 350 out of 1122 males with SLE_FG died.
Mortality risk
Mortality risk for people of age
years, who have SLE_FG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.363% |
| 5 | 0.936% | 2.409% |
| 10 | 2.457% | 5.824% |
| 15 | 4.534% | 10.77% |
| 20 | 7.396% | 17.715% |
Relationships between endpoints
↥Index endpoint: SLE_FG – SLE (Finngen)
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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