No definition available.
Drug-induced systemic lupus erythematosus
DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
226 |
4. Check minimum number of eventsNone |
226 |
5. Include endpointsNone |
226 |
6. Filter based on genotype QC (FinnGen only) |
222 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced systemic lupus erythematosus
based on the number of shared cases.
Similar with more cases:
- Systemic lupus erythematosus
- SLE (Finngen)
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1257 | 1021 | 229 |
| Only index persons | 1098 | 918 | 180 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 52.81 | 51.34 | 58.87 |
| Only index persons | 50.83 | 49.95 | 55.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 222 | 186 | 36 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.02 |
| Median age at first event (years) | 46.88 | 46.12 | 50.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT | 2.507 [2.07, 3.04] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.127 |
During the follow-up period (1.1.1998 — 31.12.2019), 239 out of 944 females with DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT | 1.985 [1.37, 2.88] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.061 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 199 males with DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.361% | 0.465% |
| 5 | 1.382% | 2.756% |
| 10 | 3.588% | 6.675% |
| 15 | 6.665% | 12.351% |
| 20 | 11.246% | 20.503% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_SYSTEMIC_LUPUS_ERYTHEMAT – Drug-induced systemic lupus erythematosus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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