connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
14789 |
6. Filter based on genotype QC (FinnGen only) |
14309 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Systemic connective tissue disorders
based on the number of shared cases.
Similar with more cases:
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 114324 | 81358 | 32067 |
| Only index persons | 95641 | 69607 | 26034 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.92 | 2.33 | 0.90 |
| Only index persons | 2.13 | 2.56 | 0.99 |
| Median age at first event (years) | |||
| Whole population | 62.72 | 61.60 | 65.43 |
| Only index persons | 60.45 | 59.02 | 64.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 14309 | 10221 | 4088 |
| Unadjusted period prevalence (%) | 3.45 | 4.01 | 2.05 |
| Median age at first event (years) | 57.75 | 54.56 | 65.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYSTCONNECT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONNECT | 1.493 [1.38, 1.62] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.072 |
During the follow-up period (1.1.1998 — 31.12.2019), 15660 out of 61396 females with M13_SYSTCONNECT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONNECT | 1.513 [1.38, 1.66] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 7595 out of 23150 males with M13_SYSTCONNECT died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYSTCONNECT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.101% | 0.242% |
| 5 | 0.823% | 1.426% |
| 10 | 2.123% | 3.792% |
| 15 | 3.918% | 7.198% |
| 20 | 6.719% | 12.455% |
Relationships between endpoints
↥Index endpoint: M13_SYSTCONNECT – Systemic connective tissue disorders
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data