Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3065 |
4. Check minimum number of eventsNone |
3065 |
5. Include endpointsNone |
3065 |
6. Filter based on genotype QC (FinnGen only) |
2981 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M35
Name in latin
Syndroma Sjögren
Similar endpoints
↥List of similar endpoints to
Sicca syndrome [Sjögren]
based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue (FG)
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19087 | 16406 | 2577 |
| Only index persons | 17279 | 15035 | 2244 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.41 | 0.47 | 0.07 |
| Only index persons | 0.49 | 0.55 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 56.27 | 56.12 | 57.14 |
| Only index persons | 55.36 | 55.28 | 55.90 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2981 | 2581 | 400 |
| Unadjusted period prevalence (%) | 0.90 | 1.01 | 0.20 |
| Median age at first event (years) | 54.03 | 53.34 | 58.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SJOGREN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SJOGREN | 1.228 [1.13, 1.34] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.569 |
During the follow-up period (1.1.1998 — 31.12.2019), 2288 out of 13453 females with M13_SJOGREN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SJOGREN | 1.337 [1.17, 1.52] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 567 out of 2104 males with M13_SJOGREN died.
Mortality risk
Mortality risk for people of age
years, who have M13_SJOGREN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.136% | 0.263% |
| 5 | 0.727% | 1.381% |
| 10 | 1.872% | 3.951% |
| 15 | 3.798% | 7.568% |
| 20 | 6.677% | 12.721% |
Relationships between endpoints
↥Index endpoint: M13_SJOGREN – Sicca syndrome [Sjögren]
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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