polymyalgia rheumatica: Polymyalgia rheumatica is a common inflammatory condition that often affects people over the age of 50 years. Characteristic symptoms are shoulder and hip girdle pain and prolonged morning stiffness. Markers of inflammation are often elevated.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4558 |
4. Check minimum number of eventsNone |
4558 |
5. Include endpointsNone |
4558 |
6. Filter based on genotype QC (FinnGen only) |
4403 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M35
Name in latin
Polymyalgia rheumatica
Similar endpoints
↥List of similar endpoints to
Polymyalgia rheumatica
based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue (FG)
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 42642 | 28465 | 13837 |
| Only index persons | 34295 | 22973 | 11322 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.67 | 0.82 | 0.39 |
| Only index persons | 0.71 | 0.84 | 0.43 |
| Median age at first event (years) | |||
| Whole population | 74.56 | 75.24 | 73.15 |
| Only index persons | 73.96 | 74.64 | 72.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4403 | 2540 | 1863 |
| Unadjusted period prevalence (%) | 0.97 | 1.00 | 0.94 |
| Median age at first event (years) | 70.86 | 70.31 | 71.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_POLYMYALGIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLYMYALGIA | 1.434 [1.32, 1.56] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.112 |
During the follow-up period (1.1.1998 — 31.12.2019), 9271 out of 20812 females with M13_POLYMYALGIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLYMYALGIA | 1.301 [1.17, 1.44] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 4250 out of 10085 males with M13_POLYMYALGIA died.
Mortality risk
Mortality risk for people of age
years, who have M13_POLYMYALGIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.255% |
| 5 | 0.776% | 1.575% |
| 10 | 2.078% | 3.809% |
| 15 | 3.839% | 7.141% |
| 20 | 6.805% | 12.182% |
Relationships between endpoints
↥Index endpoint: M13_POLYMYALGIA – Polymyalgia rheumatica
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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