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Systemic lupus erythematosus

DOID Endpoint Browser

M13_SLE

systemic lupus erythematosus: An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M32
  • Hospital discharge: ICD-9 — 7100
  • Hospital discharge: ICD-8 — 7431
  • Cause of death: ICD-10 — M32
  • Cause of death: ICD-9 — 7100
  • Cause of death: ICD-8 — 7431

2 out of 7 registries used, show all original rules.

1244

4. Check minimum number of events

None

1244

5. Include endpoints

None

1244

6. Filter based on genotype QC (FinnGen only)

1198

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M30-M36
Name in latin Lupus erythematosus disseminatus (LED)

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1198 991 207
Unadjusted period prevalence (%) 0.34 0.39 0.10
Median age at first event (years) 47.24 45.90 53.64

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: M13_SLE – Systemic lupus erythematosus

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).