No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
276 |
4. Check minimum number of eventsNone |
276 |
5. Include endpointsNone |
276 |
6. Filter based on genotype QC (FinnGen only) |
265 |
Control definitions (FinnGen only)
Control exclude
SLE_FG
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M32
Name in latin
Aliae formae lupi erythematosi disseminati (LED)
Similar endpoints
↥List of similar endpoints to
Other forms of systemic lupus erythematosus
based on the number of shared cases.
Similar with more cases:
- SLE, strict definition
- SLE, ICD10
- Systemic lupus erythematosus
- SLE (Finngen)
- Systemic connective tissue disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1584 | 1344 | 221 |
| Only index persons | 1393 | 1210 | 183 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.04 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.85 | 48.53 | 50.99 |
| Only index persons | 47.72 | 47.64 | 48.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 265 | 232 | 33 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.02 |
| Median age at first event (years) | 45.01 | 43.94 | 52.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint SLE_OTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLE_OTH | 2.654 [2.26, 3.11] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.168 |
During the follow-up period (1.1.1998 — 31.12.2019), 283 out of 1188 females with SLE_OTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SLE_OTH | 2.679 [1.67, 4.29] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 186 males with SLE_OTH died.
Mortality risk
Mortality risk for people of age
years, who have SLE_OTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.202% | 0.566% |
| 5 | 1.436% | 2.969% |
| 10 | 3.668% | 7.89% |
| 15 | 7.028% | 14.305% |
| 20 | 12.148% | 23.574% |
Relationships between endpoints
↥Index endpoint: SLE_OTH – Other forms of systemic lupus erythematosus
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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