Polyarteritis Nodosa: ['A necrotizing vasculitis that affects medium-sized arteries, it is usually idiopathic, and may be triggered by viral infections (Hepatitis B, also others). A multisystem disease, it most commonly affects skin (nodules, livedo reticularis) and peripheral nerves; higher morbidity is associated with gastrointestinal, central nervous system, cardiac, and/or other organ involvement. Anti-neutrophil cytoplasmic antibodies (ANCA) are typically negative. [ NCI ]']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
418 |
4. Check minimum number of eventsNone |
418 |
5. Include endpoints |
456 |
6. Filter based on genotype QC (FinnGen only) |
439 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M30-M36
Name in latin
Polyarteritis nodosa et condiciones cognatae
Similar endpoints
↥List of similar endpoints to
Polyarteritis nodosa and related conditions
based on the number of shared cases.
Similar with more cases:
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5194 | 2773 | 2381 |
| Only index persons | 3827 | 2036 | 1791 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.07 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 43.91 | 57.85 | 27.24 |
| Only index persons | 38.04 | 54.00 | 19.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 439 | 257 | 182 |
| Unadjusted period prevalence (%) | 0.10 | 0.10 | 0.09 |
| Median age at first event (years) | 53.52 | 52.24 | 55.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_POLYARTERETAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLYARTERETAL | 2.265 [1.92, 2.68] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.11 |
During the follow-up period (1.1.1998 — 31.12.2019), 770 out of 2094 females with M13_POLYARTERETAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLYARTERETAL | 2.27 [1.8, 2.86] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 372 out of 1721 males with M13_POLYARTERETAL died.
Mortality risk
Mortality risk for people of age
years, who have M13_POLYARTERETAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.466% |
| 5 | 1.242% | 2.493% |
| 10 | 3.117% | 6.549% |
| 15 | 6.191% | 12.498% |
| 20 | 10.063% | 20.251% |
Relationships between endpoints
↥Index endpoint: M13_POLYARTERETAL – Polyarteritis nodosa and related conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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