Polyarteritis Nodosa: ['A necrotizing vasculitis that affects medium-sized arteries, it is usually idiopathic, and may be triggered by viral infections (Hepatitis B, also others). A multisystem disease, it most commonly affects skin (nodules, livedo reticularis) and peripheral nerves; higher morbidity is associated with gastrointestinal, central nervous system, cardiac, and/or other organ involvement. Anti-neutrophil cytoplasmic antibodies (ANCA) are typically negative. [ NCI ]']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
217 |
4. Check minimum number of eventsNone |
217 |
5. Include endpointsNone |
217 |
6. Filter based on genotype QC (FinnGen only) |
213 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M30
Name in latin
Polyarteritis nodosa
Similar endpoints
↥List of similar endpoints to
Polyarteritis nodosa
based on the number of shared cases.
Similar with more cases:
- Polyarteritis nodosa and related conditions
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2412 | 1441 | 939 |
| Only index persons | 1633 | 982 | 651 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 66.80 | 70.69 | 60.69 |
| Only index persons | 61.28 | 64.65 | 56.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 213 | 118 | 95 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 59.25 | 58.77 | 59.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_POLNODOSA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLNODOSA | 2.456 [2.03, 2.97] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.939 |
During the follow-up period (1.1.1998 — 31.12.2019), 585 out of 1085 females with M13_POLNODOSA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLNODOSA | 2.422 [1.81, 3.24] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.042 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 625 males with M13_POLNODOSA died.
Mortality risk
Mortality risk for people of age
years, who have M13_POLNODOSA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.36% | 0.392% |
| 5 | 1.66% | 3.074% |
| 10 | 4.388% | 7.997% |
| 15 | 8.081% | 15.044% |
| 20 | 13.718% | 24.31% |
Relationships between endpoints
↥Index endpoint: M13_POLNODOSA – Polyarteritis nodosa
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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