No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
G6_PARKINSON, F5_PSYCH, NEURODIS
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G20-G26
Name in latin
Parkinsonismus secundarius
Similar endpoints
↥List of similar endpoints to
Secondary parkinsonism
based on the number of shared cases.
Similar with more cases:
- Secondary parkinsonism
- Secondary parkinsonism+Parkinsonism in other disease
- Extrapyramidal and movement disorders
- Neurological diseases
- Neurological diseases
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11158 | 5439 | 5530 |
| Only index persons | 7519 | 3804 | 3715 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.16 | 0.15 |
| Only index persons | 0.14 | 0.14 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 71.35 | 72.01 | 70.61 |
| Only index persons | 69.43 | 70.60 | 68.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 855 | 364 | 491 |
| Unadjusted period prevalence (%) | 0.20 | 0.14 | 0.25 |
| Median age at first event (years) | 66.15 | 65.39 | 66.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint PD2ND_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PD2ND_EXMORE | 2.661 [2.41, 2.94] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.791 |
During the follow-up period (1.1.1998 — 31.12.2019), 2267 out of 4093 females with PD2ND_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PD2ND_EXMORE | 2.923 [2.58, 3.32] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 2505 out of 4106 males with PD2ND_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have PD2ND_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.243% | 0.641% |
| 5 | 1.816% | 3.416% |
| 10 | 4.328% | 8.089% |
| 15 | 8.267% | 16.043% |
| 20 | 14.327% | 25.852% |
Relationships between endpoints
↥Index endpoint: PD2ND_EXMORE – Secondary parkinsonism
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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