basal ganglia disease: A disease involving the basal ganglia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
11938 |
4. Check minimum number of eventsNone |
11938 |
5. Include endpoints |
14646 |
6. Filter based on genotype QC (FinnGen only) |
14193 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Extrapyramidal and movement disorders
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 134703 | 69914 | 63238 |
| Only index persons | 105762 | 56932 | 48830 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.89 | 2.00 | 1.77 |
| Only index persons | 1.99 | 2.09 | 1.86 |
| Median age at first event (years) | |||
| Whole population | 67.76 | 67.76 | 67.69 |
| Only index persons | 66.50 | 66.48 | 66.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 14193 | 7650 | 6543 |
| Unadjusted period prevalence (%) | 3.13 | 3.00 | 3.29 |
| Median age at first event (years) | 64.18 | 61.72 | 67.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_XTRAPYR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_XTRAPYR | 1.71 [1.58, 1.85] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.077 |
During the follow-up period (1.1.1998 — 31.12.2019), 15474 out of 49855 females with G6_XTRAPYR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_XTRAPYR | 1.859 [1.69, 2.04] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 17700 out of 44915 males with G6_XTRAPYR died.
Mortality risk
Mortality risk for people of age
years, who have G6_XTRAPYR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.202% | 0.363% |
| 5 | 0.939% | 2.201% |
| 10 | 2.404% | 5.279% |
| 15 | 4.468% | 9.637% |
| 20 | 7.572% | 15.859% |
Relationships between endpoints
↥Index endpoint: G6_XTRAPYR – Extrapyramidal and movement disorders
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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