Parkinson's disease: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
5309 |
4. Check minimum number of eventsNone |
5309 |
5. Include endpointsNone |
5309 |
6. Filter based on genotype QC (FinnGen only) |
5150 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G20-G26
Name in latin
Morbus Parkinson
Similar endpoints
↥List of similar endpoints to
Parkinson's disease
based on the number of shared cases.
Similar with more cases:
- Parkinson's disease
- Parkinson's disease, including avohilmo
- Extrapyramidal and movement disorders
- Neurological diseases
- Neurological diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 65870 | 29924 | 34815 |
| Only index persons | 43747 | 19998 | 23749 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.92 | 0.86 | 0.97 |
| Only index persons | 0.83 | 0.74 | 0.91 |
| Median age at first event (years) | |||
| Whole population | 71.52 | 72.00 | 71.11 |
| Only index persons | 71.27 | 71.90 | 70.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5150 | 2053 | 3097 |
| Unadjusted period prevalence (%) | 1.26 | 0.81 | 1.56 |
| Median age at first event (years) | 69.01 | 67.54 | 69.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_PARKINSON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PARKINSON | 2.269 [2.1, 2.45] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.325 |
During the follow-up period (1.1.1998 — 31.12.2019), 9442 out of 18382 females with G6_PARKINSON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PARKINSON | 2.162 [1.96, 2.38] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 11970 out of 22585 males with G6_PARKINSON died.
Mortality risk
Mortality risk for people of age
years, who have G6_PARKINSON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.163% | 0.462% |
| 5 | 1.349% | 2.815% |
| 10 | 3.481% | 6.134% |
| 15 | 6.402% | 11.465% |
| 20 | 11.11% | 19.01% |
Relationships between endpoints
↥Index endpoint: G6_PARKINSON – Parkinson's disease
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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