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Secondary parkinsonism+Parkinsonism in other disease

DOID Endpoint Browser

G6_PARKSCND

postencephalitic Parkinson disease: Parkinsonism following encephalitis, historically seen as a sequella of encephalitis lethargica (Von Economo Encephalitis). The early age of onset, the rapid progression of symptoms followed by stabilization, and the presence of a variety of other neurological disorders (e.g., sociopathic behavior; TICS; MUSCLE SPASMS; oculogyric crises; hyperphagia; and bizarre movements) distinguish this condition from primary PARKINSON DISEASE. Pathologic features include neuronal loss and gliosis concentrated in the MESENCEPHALON; SUBTHALAMUS; and HYPOTHALAMUS. (From Adams et al., Principles of Neurology, 6th ed, p754)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G21, G22*, G22*A52.1
  • Hospital discharge: ICD-9 — 3321
  • Hospital discharge: ICD-8 — 3420[8-9]
  • Cause of death: ICD-10 — G21, G22*, G22*A52.1
  • Cause of death: ICD-9 — 3321
  • Cause of death: ICD-8 — 3420[8-9]

2 out of 7 registries used, show all original rules.

913

4. Check minimum number of events

None

913

5. Include endpoints

None

913

6. Filter based on genotype QC (FinnGen only)

881

Control definitions (FinnGen only)

Control exclude G6_XTRAPYR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 881 374 507
Unadjusted period prevalence (%) 0.21 0.15 0.25
Median age at first event (years) 65.69 65.13 66.11

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: G6_PARKSCND – Secondary parkinsonism+Parkinsonism in other disease

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).