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Secondary parkinsonism

PD2ND

secondary Parkinson disease: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G21
  • Hospital discharge: ICD-9 3321
  • Cause of death: ICD-10 G21
  • Cause of death: ICD-9 3321

2 out of 7 registries used, show all original rules.

885

4. Check minimum number of events

None

885

5. Include endpoints

None

885

6. Filter based on genotype QC (FinnGen only)

855

Control definitions (FinnGen only)

Control exclude G6_PARKINSON

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Parkinsonismus secundarius

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 855 364 491
Unadjusted period prevalence (%) 0.20 0.14 0.25
Median age at first event (years) 66.15 65.39 66.71

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: PD2ND – Secondary parkinsonism

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).