No definition available.
Other drug-induced secondary parkinsonism
OTHER_DRUGADVERS_SECONDA_PARKINSONI
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
286 |
4. Check minimum number of eventsNone |
286 |
5. Include endpointsNone |
286 |
6. Filter based on genotype QC (FinnGen only) |
279 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Other drug-induced secondary parkinsonism
based on the number of shared cases.
Similar with more cases:
- Secondary parkinsonism
- Secondary parkinsonism
- Secondary parkinsonism+Parkinsonism in other disease
- Extrapyramidal and movement disorders
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2777 | 1626 | 1117 |
| Only index persons | 2288 | 1355 | 933 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 68.05 | 69.66 | 65.61 |
| Only index persons | 67.29 | 68.87 | 64.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 279 | 142 | 137 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | 62.81 | 63.20 | 62.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint OTHER_DRUGADVERS_SECONDA_PARKINSONI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OTHER_DRUGADVERS_SECONDA_PARKINSONI | 2.378 [2.09, 2.71] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.129 |
During the follow-up period (1.1.1998 — 31.12.2019), 653 out of 1405 females with OTHER_DRUGADVERS_SECONDA_PARKINSONI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OTHER_DRUGADVERS_SECONDA_PARKINSONI | 2.878 [2.39, 3.47] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 476 out of 955 males with OTHER_DRUGADVERS_SECONDA_PARKINSONI died.
Mortality risk
Mortality risk for people of age
years, who have OTHER_DRUGADVERS_SECONDA_PARKINSONI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.529% |
| 5 | 1.105% | 3.197% |
| 10 | 3.376% | 7.776% |
| 15 | 6.141% | 14.768% |
| 20 | 10.724% | 23.847% |
Relationships between endpoints
↥Index endpoint: OTHER_DRUGADVERS_SECONDA_PARKINSONI – Other drug-induced secondary parkinsonism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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