basal ganglia disease: A disease involving the basal ganglia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
434 |
4. Check minimum number of eventsNone |
434 |
5. Include endpointsNone |
434 |
6. Filter based on genotype QC (FinnGen only) |
422 |
Control definitions (FinnGen only)
Control exclude
G6_XTRAPYR
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G20-G26
Name in latin
Alii morbi degenerativi gangliorum basalium
Similar endpoints
↥List of similar endpoints to
Other degenerative diseases of the basal ganglia
based on the number of shared cases.
Similar with more cases:
- Extrapyramidal and movement disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4228 | 1862 | 2313 |
| Only index persons | 3359 | 1496 | 1863 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.06 |
| Only index persons | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 72.48 | 72.52 | 72.47 |
| Only index persons | 72.80 | 72.69 | 72.90 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 422 | 160 | 262 |
| Unadjusted period prevalence (%) | 0.11 | 0.06 | 0.13 |
| Median age at first event (years) | 72.47 | 70.16 | 73.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_BASDEGENOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_BASDEGENOTH | 5.541 [4.56, 6.72] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.285 |
During the follow-up period (1.1.1998 — 31.12.2019), 710 out of 1242 females with G6_BASDEGENOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_BASDEGENOTH | 4.925 [3.86, 6.29] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 960 out of 1580 males with G6_BASDEGENOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_BASDEGENOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.511% | 0.88% |
| 5 | 3.368% | 5.096% |
| 10 | 8.029% | 12.307% |
| 15 | 14.69% | 22.676% |
| 20 | 24.56% | 35.996% |
Relationships between endpoints
↥Index endpoint: G6_BASDEGENOTH – Other degenerative diseases of the basal ganglia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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