urinary system disease: A disease involving the renal system. [database_cross_reference: MONDO:DesignPattern]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
61089 |
4. Check minimum number of eventsNone |
61089 |
5. Include endpoints |
88347 |
6. Filter based on genotype QC (FinnGen only) |
84760 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other diseases of urinary system
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 828519 | 643327 | 179136 |
| Only index persons | 718419 | 568179 | 150240 |
| Unadjusted period prevalence (%) | |||
| Whole population | 15.44 | 18.43 | 5.01 |
| Only index persons | 17.72 | 20.89 | 5.74 |
| Median age at first event (years) | |||
| Whole population | 61.52 | 59.41 | 69.32 |
| Only index persons | 59.51 | 57.15 | 68.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 84760 | 65043 | 19717 |
| Unadjusted period prevalence (%) | 21.91 | 25.55 | 9.90 |
| Median age at first event (years) | 57.43 | 53.66 | 69.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_URINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_URINOTH | 2.016 [1.87, 2.18] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 130062 out of 480938 females with N14_URINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_URINOTH | 2.323 [2.09, 2.59] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 54947 out of 137059 males with N14_URINOTH died.
Mortality risk
Mortality risk for people of age
years, who have N14_URINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.31% |
| 5 | 0.558% | 2.057% |
| 10 | 1.489% | 4.913% |
| 15 | 2.872% | 9.003% |
| 20 | 5.104% | 14.626% |
Relationships between endpoints
↥Index endpoint: N14_URINOTH – Other diseases of urinary system
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data