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Other disorders of urethra and urinary system

DOID EFO Endpoint Browser PheWeb

N14_URETHRAOTH

urethral disease: A disease involving the urethra. [database_cross_reference: MONDO:DesignPattern]

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N36, N39
  • Hospital discharge: ICD-9 — 5938B|5965|6256
  • Hospital discharge: ICD-8 — 599
  • Hospital discharge: excluded ICD-9 — 5965A
  • Cause of death: ICD-10 — N36, N39
  • Cause of death: ICD-9 — 5938B|5965|6256
  • Cause of death: ICD-8 — 599
  • Cause of death: excluded ICD-9 — 5965A

2 out of 7 registries used, show all original rules.

42657

4. Check minimum number of events

None

42657

5. Include endpoints

None

42657

6. Filter based on genotype QC (FinnGen only)

41021

Control definitions (FinnGen only)

Control exclude N14_URINOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 407456 317974 86689
Only index persons 346087 274748 71339
Unadjusted period prevalence (%)
Whole population 7.64 9.11 2.42
Only index persons 8.58 10.10 2.72
Median age at first event (years)
Whole population 67.22 65.78 72.37
Only index persons 64.53 62.76 71.36

-FinnGen-

Key figures

All Female Male
Number of individuals 41021 31827 9194
Unadjusted period prevalence (%) 10.73 12.50 4.62
Median age at first event (years) 58.91 55.17 71.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_URETHRAOTH and mortality.

Females

Parameter HR [95% CI] p-value
N14_URETHRAOTH 2.004 [1.85, 2.17] < 0.001
Birth year 0.991 [0.98, 1.0] 0.02

During the follow-up period (1.1.1998 — 31.12.2019), 88622 out of 251061 females with N14_URETHRAOTH died.

Males

Parameter HR [95% CI] p-value
N14_URETHRAOTH 2.53 [2.24, 2.85] < 0.001
Birth year 0.986 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 33009 out of 67625 males with N14_URETHRAOTH died.

Mortality risk

Mortality risk for people of age

years, who have N14_URETHRAOTH.

N-year risk Females Males
1 0.154% 0.383%
5 1.015% 2.418%
10 2.211% 6.022%
15 4.02% 10.967%
20 6.899% 18.724%

Relationships between endpoints

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Index endpoint: N14_URETHRAOTH – Other disorders of urethra and urinary system

GWS hits: 7

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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