No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3290 |
4. Check minimum number of eventsNone |
3290 |
5. Include endpointsNone |
3290 |
6. Filter based on genotype QC (FinnGen only) |
3171 |
Control definitions (FinnGen only)
Control exclude
N14_URINOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N30-N39
Name in latin
Dysfunctiones neuromusculares vesicae urinarie non alibi classificatae
Neuromuscular dysfunction of bladder
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22809 | 10056 | 12601 |
| Only index persons | 20506 | 9237 | 11269 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.32 | 0.29 | 0.35 |
| Only index persons | 0.39 | 0.34 | 0.43 |
| Median age at first event (years) | |||
| Whole population | 63.11 | 60.84 | 64.84 |
| Only index persons | 61.96 | 59.61 | 63.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3171 | 1568 | 1603 |
| Unadjusted period prevalence (%) | 0.71 | 0.62 | 0.81 |
| Median age at first event (years) | 59.95 | 53.95 | 65.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_NEUROMUSCDYSBLADD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEUROMUSCDYSBLADD | 1.558 [1.41, 1.72] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.76 |
During the follow-up period (1.1.1998 — 31.12.2019), 2125 out of 8622 females with N14_NEUROMUSCDYSBLADD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEUROMUSCDYSBLADD | 1.857 [1.67, 2.07] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 3480 out of 10789 males with N14_NEUROMUSCDYSBLADD died.
Mortality risk
Mortality risk for people of age
years, who have N14_NEUROMUSCDYSBLADD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.229% |
| 5 | 0.921% | 1.829% |
| 10 | 2.246% | 5.209% |
| 15 | 4.56% | 9.634% |
| 20 | 8.219% | 15.884% |
Relationships between endpoints
↥Index endpoint: N14_NEUROMUSCDYSBLADD – Neuromuscular dysfunction of bladder
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data