bladder disease: A disorder affecting the urinary bladder
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4356 |
4. Check minimum number of eventsNone |
4356 |
5. Include endpointsNone |
4356 |
6. Filter based on genotype QC (FinnGen only) |
4194 |
Control definitions (FinnGen only)
Control exclude
N14_URINOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N30-N39
Name in latin
Aliae morbositates vesicae urinariae
Other disorders of bladder
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 29331 | 9928 | 19114 |
| Only index persons | 25357 | 8786 | 16571 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.45 | 0.28 | 0.53 |
| Only index persons | 0.53 | 0.32 | 0.63 |
| Median age at first event (years) | |||
| Whole population | 64.82 | 61.05 | 66.73 |
| Only index persons | 63.94 | 59.97 | 66.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4194 | 1377 | 2817 |
| Unadjusted period prevalence (%) | 1.13 | 0.54 | 1.41 |
| Median age at first event (years) | 63.75 | 56.60 | 67.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_OTHBLADD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_OTHBLADD | 1.605 [1.43, 1.8] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.996 |
During the follow-up period (1.1.1998 — 31.12.2019), 1671 out of 7089 females with N14_OTHBLADD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_OTHBLADD | 1.355 [1.24, 1.48] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 4891 out of 15232 males with N14_OTHBLADD died.
Mortality risk
Mortality risk for people of age
years, who have N14_OTHBLADD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.175% | 0.192% |
| 5 | 1.043% | 1.366% |
| 10 | 2.702% | 3.509% |
| 15 | 5.416% | 6.588% |
| 20 | 9.541% | 11.165% |
Relationships between endpoints
↥Index endpoint: N14_OTHBLADD – Other disorders of bladder
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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