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Cystitis

DOID EFO Endpoint Browser PheWeb

N14_CYSTITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — N30
  • Hospital discharge: ICD-10 — N30
  • Hospital discharge: ICD-9 — 595
  • Hospital discharge: ICD-8 — 595
  • Cause of death: ICD-10 — N30
  • Cause of death: ICD-9 — 595
  • Cause of death: ICD-8 — 595

3 out of 7 registries used, show all original rules.

54869

4. Check minimum number of events

None

54869

5. Include endpoints

None

54869

6. Filter based on genotype QC (FinnGen only)

52581

Control definitions (FinnGen only)

Control exclude N14_URINOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF10
Parent code in ICD-10 N30-N39
Name in latin Cystitis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 514398 428108 82838
Only index persons 458475 387010 71465
Unadjusted period prevalence (%)
Whole population 10.60 12.26 2.31
Only index persons 12.43 14.23 2.73
Median age at first event (years)
Whole population 62.07 60.43 71.49
Only index persons 60.96 59.08 71.18

-FinnGen-

Key figures

All Female Male
Number of individuals 52581 43366 9215
Unadjusted period prevalence (%) 14.86 17.03 4.63
Median age at first event (years) 59.04 56.29 71.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_CYSTITIS and mortality.

Females

Parameter HR [95% CI] p-value
N14_CYSTITIS 1.91 [1.73, 2.11] < 0.001
Birth year 0.989 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 77340 out of 312189 females with N14_CYSTITIS died.

Males

Parameter HR [95% CI] p-value
N14_CYSTITIS 2.303 [2.01, 2.64] < 0.001
Birth year 0.991 [0.98, 1.0] 0.038

During the follow-up period (1.1.1998 — 31.12.2019), 24788 out of 62375 males with N14_CYSTITIS died.

Mortality risk

Mortality risk for people of age

years, who have N14_CYSTITIS.

N-year risk Females Males
1 0.163% 0.413%
5 0.875% 2.325%
10 2.05% 6.096%
15 3.68% 11.834%
20 6.065% 20.281%

Relationships between endpoints

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Index endpoint: N14_CYSTITIS – Cystitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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