Other enthesopathies

M13_ENTESOPATHYOTH

enthesopathy: A disorder involving the attachment of a tendon or ligament to a bone [database_cross_reference: https://en.wikipedia.org/wiki/Enthesopathy]

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M77
  • Cause of death: ICD-10 M77

2 out of 7 registries used, show all original rules.

11025

4. Check minimum number of events

None

11025

5. Include endpoints

13589

6. Filter based on genotype QC (FinnGen only)

13102

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M70-M79
Name in latin Aliae enthesopathiae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 97536 57870 39147
Only index persons 91332 55371 35961
Unadjusted period prevalence (%)
Whole population 1.43 1.66 1.09
Only index persons 1.77 2.04 1.37
Median age at first event (years)
Whole population 46.17 47.28 44.51
Only index persons 45.87 47.04 44.06

-FinnGen-

Key figures

All Female Male
Number of individuals 13102 8582 4520
Unadjusted period prevalence (%) 2.99 3.37 2.27
Median age at first event (years) 47.90 47.94 47.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_ENTESOPATHYOTH and mortality.

Females

Parameter HR [95% CI] p-value
M13_ENTESOPATHYOTH 0.899 [0.81, 1.0] 0.048
Birth year 0.994 [0.99, 1.0] 0.123

During the follow-up period (1.1.1998 — 31.12.2019), 2038 out of 38096 females with M13_ENTESOPATHYOTH died.

Males

Parameter HR [95% CI] p-value
M13_ENTESOPATHYOTH 0.86 [0.78, 0.95] 0.004
Birth year 0.984 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1759 out of 23239 males with M13_ENTESOPATHYOTH died.

Mortality risk

Mortality risk for people of age

years, who have M13_ENTESOPATHYOTH.

N-year risk Females Males
1 0.079% 0.135%
5 0.467% 0.793%
10 1.142% 2.13%
15 2.323% 4.391%
20 4.154% 7.548%

Relationships between endpoints

Index endpoint: M13_ENTESOPATHYOTH – Other enthesopathies

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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