Calcaneal spur

M13_CALCANSPUR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M77.3
  • Hospital discharge: ICD-9 7267C
  • Cause of death: ICD-10 M77.3
  • Cause of death: ICD-9 7267C

2 out of 7 registries used, show all original rules.

404

4. Check minimum number of events

None

404

5. Include endpoints

None

404

6. Filter based on genotype QC (FinnGen only)

388

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M77
Name in latin Calcar calcanei

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2720 1874 838
Only index persons 2587 1803 784
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.02
Only index persons 0.06 0.07 0.03
Median age at first event (years)
Whole population 50.76 50.96 50.30
Only index persons 50.62 50.84 50.14

-FinnGen-

Key figures

All Female Male
Number of individuals 388 287 101
Unadjusted period prevalence (%) 0.10 0.11 0.05
Median age at first event (years) 50.39 50.14 51.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint M13_CALCANSPUR and mortality.

Females

Parameter HR [95% CI] p-value
M13_CALCANSPUR 0.732 [0.58, 0.92] 0.007
Birth year 1.001 [0.99, 1.01] 0.826

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 1118 females with M13_CALCANSPUR died.

Males

Parameter HR [95% CI] p-value
M13_CALCANSPUR 0.878 [0.67, 1.14] 0.333
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 505 males with M13_CALCANSPUR died.

Mortality risk

Mortality risk for people of age

years, who have M13_CALCANSPUR.

N-year risk Females Males
1 0.081% 0.161%
5 0.563% 0.926%
10 1.335% 2.199%
15 2.585% 4.304%
20 4.505% 7.431%

Relationships between endpoints

Index endpoint: M13_CALCANSPUR – Calcaneal spur

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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