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Other/unspecified enthesopathies, not elsewhere classified

DOID EFO Endpoint Browser PheWeb

M13_ENTESOPATHYNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M77.8, M77.9
  • Hospital discharge: ICD-9 — 726[8-9]
  • Hospital discharge: ICD-8 — 7310[5-9]
  • Cause of death: ICD-10 — M77.8, M77.9
  • Cause of death: ICD-9 — 726[8-9]
  • Cause of death: ICD-8 — 7310[5-9]

2 out of 7 registries used, show all original rules.

3433

4. Check minimum number of events

None

3433

5. Include endpoints

None

3433

6. Filter based on genotype QC (FinnGen only)

3312

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 29123 15656 13222
Only index persons 24890 13949 10941
Unadjusted period prevalence (%)
Whole population 0.41 0.45 0.37
Only index persons 0.47 0.51 0.42
Median age at first event (years)
Whole population 41.06 43.40 38.11
Only index persons 38.89 41.57 35.48

-FinnGen-

Key figures

All Female Male
Number of individuals 3312 1917 1395
Unadjusted period prevalence (%) 0.73 0.75 0.70
Median age at first event (years) 40.63 41.18 39.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_ENTESOPATHYNAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_ENTESOPATHYNAS 0.993 [0.87, 1.13] 0.921
Birth year 0.992 [0.98, 1.0] 0.068

During the follow-up period (1.1.1998 — 31.12.2019), 417 out of 5360 females with M13_ENTESOPATHYNAS died.

Males

Parameter HR [95% CI] p-value
M13_ENTESOPATHYNAS 0.935 [0.82, 1.07] 0.332
Birth year 0.985 [0.97, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 350 out of 3720 males with M13_ENTESOPATHYNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_ENTESOPATHYNAS.

N-year risk Females Males
1 0.089% 0.167%
5 0.59% 1.146%
10 1.437% 2.742%
15 2.609% 4.978%
20 4.271% 8.315%

Relationships between endpoints

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Index endpoint: M13_ENTESOPATHYNAS – Other/unspecified enthesopathies, not elsewhere classified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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