urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
13131 |
6. Filter based on genotype QC (FinnGen only) |
12576 |
Control definitions (FinnGen only)
Control exclude
L12_URTICARIAERYTHEMA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 124519 | 74623 | 49255 |
| Only index persons | 107603 | 66438 | 41165 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.83 | 2.14 | 1.38 |
| Only index persons | 2.11 | 2.44 | 1.57 |
| Median age at first event (years) | |||
| Whole population | 28.88 | 34.31 | 20.52 |
| Only index persons | 31.37 | 35.90 | 24.05 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12576 | 9018 | 3558 |
| Unadjusted period prevalence (%) | 3.05 | 3.54 | 1.79 |
| Median age at first event (years) | 41.39 | 40.63 | 43.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTICARIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICARIA | 1.132 [1.02, 1.26] | 0.02 |
| Birth year | 0.998 [0.99, 1.01] | 0.56 |
During the follow-up period (1.1.1998 — 31.12.2019), 3429 out of 56509 females with L12_URTICARIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICARIA | 1.143 [1.02, 1.28] | 0.025 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2360 out of 35026 males with L12_URTICARIA died.
Mortality risk
Mortality risk for people of age
years, who have L12_URTICARIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | 0.175% |
| 5 | 0.728% | 1.207% |
| 10 | 1.81% | 3.291% |
| 15 | 3.58% | 6.228% |
| 20 | 6.254% | 10.121% |
Relationships between endpoints
↥Index endpoint: L12_URTICARIA – Urticaria
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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