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This is a non-core endpoint: only basic statistics are computed.

Vibratory urticaria

L12_URTICA_VIBR

vibratory urticaria: This very rare form of angioedema develops in reply to contact with vibration. In vibratory angioedema, symptoms develop within two to five minutes after contact with vibration and dissolve after about an hour. Patients with this disorder do not suffer from dermographism or pressure urticaria. Vibratory angioedema is diagnosed by holding a vibrating device such as a laboratory vortex machine against the forearm for four minutes. Speedy swelling of the whole forearm extending into the upper arm is also noted later. The principal treatment is avoidance of vibratory stimulants. Antihistamines have also been proven helpful.[

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L50.4
  • Hospital discharge: ICD-9 7084
  • Cause of death: ICD-10 L50.4
  • Cause of death: ICD-9 7084

2 out of 7 registries used, show all original rules.

25

4. Check minimum number of events

None

25

5. Include endpoints

None

25

6. Filter based on genotype QC (FinnGen only)

25

Control definitions (FinnGen only)

Control exclude L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L50
Name in latin Urticaria ex vibratione

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 154 107 45
Only index persons 138 99 39
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 47.17 48.81 42.73
Only index persons 45.55 47.80 39.84

-FinnGen-

Key figures

All Female Male
Number of individuals 25 18 7
Unadjusted period prevalence (%) 0.01 0.01 0.00
Median age at first event (years) 52.42 51.13 55.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint L12_URTICA_VIBR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_URTICA_VIBR.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_URTICA_VIBR – Vibratory urticaria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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