urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
685 |
4. Check minimum number of eventsNone |
685 |
5. Include endpointsNone |
685 |
6. Filter based on genotype QC (FinnGen only) |
658 |
Control definitions (FinnGen only)
Control exclude
L12_URTICARIAERYTHEMA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50
Name in latin
Urticaria idiopathica
Similar endpoints
↥List of similar endpoints to
Idiopathic urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5662 | 3560 | 2061 |
| Only index persons | 5072 | 3268 | 1804 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.06 |
| Only index persons | 0.10 | 0.12 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 30.93 | 35.13 | 23.53 |
| Only index persons | 33.36 | 36.62 | 27.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 658 | 495 | 163 |
| Unadjusted period prevalence (%) | 0.17 | 0.19 | 0.08 |
| Median age at first event (years) | 43.26 | 41.90 | 47.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTICA_IDIOPAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_IDIOPAT | 1.082 [0.86, 1.37] | 0.511 |
| Birth year | 0.995 [0.99, 1.0] | 0.272 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 2558 females with L12_URTICA_IDIOPAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_IDIOPAT | 1.073 [0.8, 1.43] | 0.632 |
| Birth year | 0.991 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 1446 males with L12_URTICA_IDIOPAT died.
Mortality risk
Mortality risk for people of age
years, who have L12_URTICA_IDIOPAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.229% |
| 5 | 0.676% | 1.245% |
| 10 | 1.577% | 3.287% |
| 15 | 3.005% | 6.357% |
| 20 | 5.357% | 10.726% |
Relationships between endpoints
↥Index endpoint: L12_URTICA_IDIOPAT – Idiopathic urticaria
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data