dermatographia: Familial dermographism is a condition also known as skin writing. When people who have dermatographia lightly scratch their skin, the scratches redden into a raised wheal similar to hives. Signs and symptoms of dermatographia include raised red lines, swelling, inflammation, hive-like welts and itching. Symptoms usually disappear within 30 minutes. The exact cause of this condition is unknown. Treatment mayinvovle use of antihistamines if symptoms do not go away on their own.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2468 |
4. Check minimum number of eventsNone |
2468 |
5. Include endpointsNone |
2468 |
6. Filter based on genotype QC (FinnGen only) |
2359 |
Control definitions (FinnGen only)
Control exclude
L12_URTICARIAERYTHEMA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50
Name in latin
Urticaria derm[at]ographica
Similar endpoints
↥List of similar endpoints to
Dermatographic urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15685 | 11264 | 4351 |
| Only index persons | 15227 | 11048 | 4179 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.32 | 0.12 |
| Only index persons | 0.34 | 0.41 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 41.50 | 41.98 | 40.28 |
| Only index persons | 41.59 | 42.07 | 40.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2359 | 1876 | 483 |
| Unadjusted period prevalence (%) | 0.64 | 0.74 | 0.24 |
| Median age at first event (years) | 45.85 | 44.41 | 51.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTICA_DERTMATOG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_DERTMATOG | 0.738 [0.63, 0.86] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.16 |
During the follow-up period (1.1.1998 — 31.12.2019), 366 out of 9810 females with L12_URTICA_DERTMATOG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_DERTMATOG | 0.818 [0.71, 0.94] | 0.006 |
| Birth year | 0.996 [0.99, 1.01] | 0.415 |
During the follow-up period (1.1.1998 — 31.12.2019), 289 out of 3744 males with L12_URTICA_DERTMATOG died.
Mortality risk
Mortality risk for people of age
years, who have L12_URTICA_DERTMATOG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.179% |
| 5 | 0.449% | 1.141% |
| 10 | 1.149% | 2.936% |
| 15 | 2.057% | 5.859% |
| 20 | 3.711% | 10.096% |
Relationships between endpoints
↥Index endpoint: L12_URTICA_DERTMATOG – Dermatographic urticaria
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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