allergic urticaria: commonly referred to as hives, is a kind of skin rash notable for pale red, raised, itchy bumps. Hives may cause a burning or stinging sensation. Histamine and other proinflammatory substances are released from mast cells in the skin and tissues in response to the binding of allergen-bound IgE antibodies to high-affinity cell surface receptors. Basophils and other inflammatory cells are also seen to release histamine and other mediators, and are thought to play an important role, especially in chronic urticarial diseases.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3085 |
4. Check minimum number of eventsNone |
3085 |
5. Include endpointsNone |
3085 |
6. Filter based on genotype QC (FinnGen only) |
2944 |
Control definitions (FinnGen only)
Control exclude
L12_URTICARIAERYTHEMA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50
Name in latin
Urticaria allergica
Similar endpoints
↥List of similar endpoints to
Allergic urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 34186 | 19774 | 14249 |
| Only index persons | 28832 | 17219 | 11613 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.49 | 0.57 | 0.40 |
| Only index persons | 0.56 | 0.63 | 0.44 |
| Median age at first event (years) | |||
| Whole population | 25.34 | 32.25 | 15.58 |
| Only index persons | 28.78 | 34.54 | 20.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2944 | 2085 | 859 |
| Unadjusted period prevalence (%) | 0.71 | 0.82 | 0.43 |
| Median age at first event (years) | 42.33 | 40.70 | 46.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTICA_ALLERG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_ALLERG | 1.201 [1.06, 1.36] | 0.004 |
| Birth year | 0.998 [0.99, 1.01] | 0.694 |
During the follow-up period (1.1.1998 — 31.12.2019), 1258 out of 15742 females with L12_URTICA_ALLERG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_ALLERG | 1.402 [1.22, 1.61] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 791 out of 11004 males with L12_URTICA_ALLERG died.
Mortality risk
Mortality risk for people of age
years, who have L12_URTICA_ALLERG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.141% | 0.233% |
| 5 | 0.869% | 1.554% |
| 10 | 2.144% | 4.065% |
| 15 | 3.882% | 7.337% |
| 20 | 6.668% | 12.586% |
Relationships between endpoints
↥Index endpoint: L12_URTICA_ALLERG – Allergic urticaria
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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