urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
8113 |
4. Check minimum number of eventsNone |
8113 |
5. Include endpointsNone |
8113 |
6. Filter based on genotype QC (FinnGen only) |
7778 |
Control definitions (FinnGen only)
Control exclude
L12_URTICARIAERYTHEMA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 77117 | 45690 | 31011 |
| Only index persons | 66004 | 40315 | 25689 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.13 | 1.31 | 0.87 |
| Only index persons | 1.29 | 1.48 | 0.98 |
| Median age at first event (years) | |||
| Whole population | 28.20 | 33.41 | 20.39 |
| Only index persons | 30.53 | 35.04 | 23.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7778 | 5537 | 2241 |
| Unadjusted period prevalence (%) | 1.87 | 2.17 | 1.13 |
| Median age at first event (years) | 39.98 | 39.71 | 40.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTICA_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_NAS | 1.137 [1.01, 1.28] | 0.03 |
| Birth year | 0.995 [0.99, 1.0] | 0.225 |
During the follow-up period (1.1.1998 — 31.12.2019), 1906 out of 33280 females with L12_URTICA_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_NAS | 1.127 [0.99, 1.28] | 0.066 |
| Birth year | 0.986 [0.97, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 1363 out of 21008 males with L12_URTICA_NAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_URTICA_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.22% |
| 5 | 0.602% | 1.272% |
| 10 | 1.525% | 3.369% |
| 15 | 2.983% | 6.249% |
| 20 | 5.724% | 10.368% |
Relationships between endpoints
↥Index endpoint: L12_URTICA_NAS – Other and unspecified urticaria
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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