≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Schizophrenia or delusion

Endpoint Browser PheWeb

KRA_PSY_SCHIZODEL_EXMORE

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F20-F29
  • Hospital discharge: ICD-9 — 295|29[7-8]
  • Hospital discharge: ICD-8 — 295|297|298[1-9]|299
  • Cause of death: ICD-10 — F20-F29
  • Cause of death: ICD-9 — 295|29[7-8]
  • Cause of death: ICD-8 — 295|297|298[1-9]|299

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 172928 88075 83096
Only index persons 139867 72267 67600
Unadjusted period prevalence (%)
Whole population 2.42 2.52 2.32
Only index persons 2.62 2.66 2.58
Median age at first event (years)
Whole population 36.91 40.89 32.51
Only index persons 34.40 37.73 30.84

-FinnGen-

Key figures

All Female Male
Number of individuals 14529 7628 6901
Unadjusted period prevalence (%) 3.22 3.00 3.47
Median age at first event (years) 30.94 32.06 29.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint KRA_PSY_SCHIZODEL_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_SCHIZODEL_EXMORE 2.145 [1.96, 2.35] < 0.001
Birth year 0.991 [0.98, 1.0] 0.032

During the follow-up period (1.1.1998 — 31.12.2019), 10644 out of 45404 females with KRA_PSY_SCHIZODEL_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_SCHIZODEL_EXMORE 3.106 [2.82, 3.42] < 0.001
Birth year 0.988 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 9185 out of 44428 males with KRA_PSY_SCHIZODEL_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_SCHIZODEL_EXMORE.

N-year risk Females Males
1 0.17% 0.511%
5 1.316% 3.579%
10 2.946% 8.147%
15 5.403% 16.0%
20 8.839% 26.05%

Relationships between endpoints

↥

Index endpoint: KRA_PSY_SCHIZODEL_EXMORE – Schizophrenia or delusion

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data