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Persistent delusional disorders

DOID EFO Endpoint Browser PheWeb

F5_DELUSIO

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F22
  • Hospital discharge: ICD-9 — 2971
  • Hospital discharge: ICD-8 — 297
  • Cause of death: ICD-10 — F22
  • Cause of death: ICD-9 — 2971
  • Cause of death: ICD-8 — 297

2 out of 7 registries used, show all original rules.

2854

4. Check minimum number of events

None

2854

5. Include endpoints

None

2854

6. Filter based on genotype QC (FinnGen only)

2729

Control definitions (FinnGen only)

Control exclude F5_SCHIZO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F20-F29
Name in latin Perturbationes delusionales persistentes

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 38824 23201 15266
Only index persons 30346 18429 11917
Unadjusted period prevalence (%)
Whole population 0.57 0.66 0.43
Only index persons 0.59 0.68 0.45
Median age at first event (years)
Whole population 57.29 63.88 47.22
Only index persons 54.89 61.61 44.51

-FinnGen-

Key figures

All Female Male
Number of individuals 2729 1499 1230
Unadjusted period prevalence (%) 0.60 0.59 0.62
Median age at first event (years) 47.33 51.28 42.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_DELUSIO and mortality.

Females

Parameter HR [95% CI] p-value
F5_DELUSIO 1.636 [1.51, 1.78] < 0.001
Birth year 1.001 [0.99, 1.01] 0.89

During the follow-up period (1.1.1998 — 31.12.2019), 5697 out of 15031 females with F5_DELUSIO died.

Males

Parameter HR [95% CI] p-value
F5_DELUSIO 2.41 [2.17, 2.68] < 0.001
Birth year 0.99 [0.98, 1.0] 0.035

During the follow-up period (1.1.1998 — 31.12.2019), 2977 out of 9525 males with F5_DELUSIO died.

Mortality risk

Mortality risk for people of age

years, who have F5_DELUSIO.

N-year risk Females Males
1 0.176% 0.508%
5 1.142% 2.751%
10 2.591% 7.179%
15 5.227% 13.059%
20 9.441% 21.687%

Relationships between endpoints

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Index endpoint: F5_DELUSIO – Persistent delusional disorders

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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