schizoaffective disorder: A disorder in which the individual suffers from both symptoms that qualify as schizophrenia and symptoms that qualify as a mood disorder (e.g., depression or bipolar disorder) for a substantial portion (but not all) of the active period of the illness; for the remainder of the active period of the illness, the individual suffers from delusions or hallucinations in the absence of prominent mood symptoms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3082 |
4. Check minimum number of eventsNone |
3082 |
5. Include endpointsNone |
3082 |
6. Filter based on genotype QC (FinnGen only) |
2945 |
Control definitions (FinnGen only)
Control exclude
F5_SCHIZO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F20-F29
Name in latin
Perturbationes schizoaffectivae
Similar endpoints
↥List of similar endpoints to
Schizoaffective disorder
based on the number of shared cases.
Similar with more cases:
- Schizophrenia or delusion
- Schizophrenia or delusion
- Schizophrenia, schizotypal and delusional disorders
- Affective disorder, aux endpoint for F5_SAD
- Any mental disorder
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19879 | 11140 | 8568 |
| Only index persons | 17035 | 9776 | 7259 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.32 | 0.24 |
| Only index persons | 0.32 | 0.36 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 37.27 | 38.72 | 35.28 |
| Only index persons | 36.54 | 37.90 | 34.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2945 | 1754 | 1191 |
| Unadjusted period prevalence (%) | 0.65 | 0.69 | 0.60 |
| Median age at first event (years) | 35.19 | 35.61 | 34.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_SCHIZOAFF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SCHIZOAFF | 3.131 [2.78, 3.53] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.05 |
During the follow-up period (1.1.1998 — 31.12.2019), 1073 out of 6730 females with F5_SCHIZOAFF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SCHIZOAFF | 3.091 [2.74, 3.48] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 1030 out of 5175 males with F5_SCHIZOAFF died.
Mortality risk
Mortality risk for people of age
years, who have F5_SCHIZOAFF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.26% | 0.601% |
| 5 | 1.773% | 3.594% |
| 10 | 3.971% | 8.955% |
| 15 | 7.707% | 16.974% |
| 20 | 13.159% | 26.708% |
Relationships between endpoints
↥Index endpoint: F5_SCHIZOAFF – Schizoaffective disorder
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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