psychosis: An abnormal condition of the mind that involves a loss of contact with reality. People experiencing psychosis may exhibit personality changes and thought disorder. Depending on its severity, this may be accompanied by unusual or bizarre behavior, as well as difficulty with social interaction and impairment in carrying out daily life activities.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
8863 |
4. Check minimum number of eventsNone |
8863 |
5. Include endpointsNone |
8863 |
6. Filter based on genotype QC (FinnGen only) |
8409 |
Control definitions (FinnGen only)
Control exclude
F5_SCHIZO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified nonorganic psychotic disorders
based on the number of shared cases.
Similar with more cases:
- Schizophrenia or delusion
- Schizophrenia or delusion
- Schizophrenia, schizotypal and delusional disorders
- Any mental disorder
- Psychiatric diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 88022 | 43237 | 44010 |
| Only index persons | 76933 | 38292 | 38641 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.23 | 1.24 | 1.23 |
| Only index persons | 1.44 | 1.41 | 1.48 |
| Median age at first event (years) | |||
| Whole population | 34.75 | 38.19 | 31.23 |
| Only index persons | 33.05 | 36.04 | 30.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8409 | 4502 | 3907 |
| Unadjusted period prevalence (%) | 1.86 | 1.77 | 1.96 |
| Median age at first event (years) | 30.91 | 32.05 | 29.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_PSYCHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PSYCHOTH | 2.528 [2.31, 2.77] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.128 |
During the follow-up period (1.1.1998 — 31.12.2019), 4722 out of 28529 females with F5_PSYCHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PSYCHOTH | 3.803 [3.44, 4.2] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 4982 out of 30135 males with F5_PSYCHOTH died.
Mortality risk
Mortality risk for people of age
years, who have F5_PSYCHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.312% | 0.784% |
| 5 | 1.576% | 3.915% |
| 10 | 3.537% | 10.138% |
| 15 | 6.712% | 18.852% |
| 20 | 11.113% | 31.326% |
Relationships between endpoints
↥Index endpoint: F5_PSYCHOTH – Other and unspecified nonorganic psychotic disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data