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Schizophrenia

DOID EFO Endpoint Browser PheWeb

F5_SCHZPHR

schizophrenia: A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F20
  • Hospital discharge: ICD-9 — 295
  • Hospital discharge: ICD-8 — 295
  • Hospital discharge: excluded ICD-9 — 2954|2957
  • Hospital discharge: excluded ICD-8 — 2957
  • Cause of death: ICD-10 — F20
  • Cause of death: ICD-9 — 295
  • Cause of death: ICD-8 — 295
  • Cause of death: excluded ICD-9 — 2954|2957
  • Cause of death: excluded ICD-8 — 2957

2 out of 7 registries used, show all original rules.

7209

4. Check minimum number of events

None

7209

5. Include endpoints

None

7209

6. Filter based on genotype QC (FinnGen only)

6933

Control definitions (FinnGen only)

Control exclude F5_SCHIZO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F20-F29
Name in latin Schizophrenia

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 69834 33018 36128
Only index persons 55372 26366 29006
Unadjusted period prevalence (%)
Whole population 0.98 0.95 1.01
Only index persons 1.04 0.97 1.11
Median age at first event (years)
Whole population 33.95 37.21 30.80
Only index persons 32.39 35.12 29.90

-FinnGen-

Key figures

All Female Male
Number of individuals 6933 3131 3802
Unadjusted period prevalence (%) 1.60 1.23 1.91
Median age at first event (years) 29.37 30.15 28.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_SCHZPHR and mortality.

Females

Parameter HR [95% CI] p-value
F5_SCHZPHR 2.538 [2.31, 2.79] < 0.001
Birth year 1.0 [0.99, 1.01] 0.945

During the follow-up period (1.1.1998 — 31.12.2019), 2673 out of 12837 females with F5_SCHZPHR died.

Males

Parameter HR [95% CI] p-value
F5_SCHZPHR 3.467 [3.15, 3.81] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2921 out of 15734 males with F5_SCHZPHR died.

Mortality risk

Mortality risk for people of age

years, who have F5_SCHZPHR.

N-year risk Females Males
1 0.237% 0.543%
5 1.347% 3.481%
10 3.932% 8.162%
15 7.645% 15.011%
20 13.697% 24.556%

Relationships between endpoints

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Index endpoint: F5_SCHZPHR – Schizophrenia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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