Other diseases of pleura

J10_PLEURA

respiratory system disease: A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

17939

4. Check minimum number of events

None

17939

5. Include endpoints

19120

6. Filter based on genotype QC (FinnGen only)

18491

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 165367 60443 102616
Only index persons 126825 47803 79022
Unadjusted period prevalence (%)
Whole population 2.45 1.73 2.87
Only index persons 2.54 1.76 3.02
Median age at first event (years)
Whole population 67.95 69.97 66.73
Only index persons 67.32 69.49 66.00

-FinnGen-

Key figures

All Female Male
Number of individuals 18491 5941 12550
Unadjusted period prevalence (%) 5.03 2.33 6.30
Median age at first event (years) 67.38 64.92 68.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_PLEURA and mortality.

Females

Parameter HR [95% CI] p-value
J10_PLEURA 4.103 [3.68, 4.57] < 0.001
Birth year 0.994 [0.98, 1.0] 0.2

During the follow-up period (1.1.1998 — 31.12.2019), 22844 out of 42469 females with J10_PLEURA died.

Males

Parameter HR [95% CI] p-value
J10_PLEURA 3.126 [2.82, 3.47] < 0.001
Birth year 0.985 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 36181 out of 70732 males with J10_PLEURA died.

Mortality risk

Mortality risk for people of age

years, who have J10_PLEURA.

N-year risk Females Males
1 0.332% 0.58%
5 2.43% 3.205%
10 5.677% 7.709%
15 10.203% 14.25%
20 16.831% 22.497%

Relationships between endpoints

Index endpoint: J10_PLEURA – Other diseases of pleura

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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