respiratory system disease: A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
17939 |
4. Check minimum number of eventsNone |
17939 |
5. Include endpoints |
19120 |
6. Filter based on genotype QC (FinnGen only) |
18491 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 165367 | 60443 | 102616 |
Only index persons | 126825 | 47803 | 79022 |
Unadjusted period prevalence (%) | |||
Whole population | 2.45 | 1.73 | 2.87 |
Only index persons | 2.54 | 1.76 | 3.02 |
Median age at first event (years) | |||
Whole population | 67.95 | 69.97 | 66.73 |
Only index persons | 67.32 | 69.49 | 66.00 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 18491 | 5941 | 12550 |
Unadjusted period prevalence (%) | 5.03 | 2.33 | 6.30 |
Median age at first event (years) | 67.38 | 64.92 | 68.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_PLEURA and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_PLEURA | 4.103 [3.68, 4.57] | < 0.001 |
Birth year | 0.994 [0.98, 1.0] | 0.2 |
During the follow-up period (1.1.1998 — 31.12.2019), 22844 out of 42469 females with J10_PLEURA died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_PLEURA | 3.126 [2.82, 3.47] | < 0.001 |
Birth year | 0.985 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 36181 out of 70732 males with J10_PLEURA died.
Mortality risk
Mortality risk for people of age
years, who have J10_PLEURA.N-year risk | Females | Males |
---|---|---|
1 | 0.332% | 0.58% |
5 | 2.43% | 3.205% |
10 | 5.677% | 7.709% |
15 | 10.203% | 14.25% |
20 | 16.831% | 22.497% |
Relationships between endpoints
↥Index endpoint: J10_PLEURA – Other diseases of pleura
GWS hits: 3