≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Pleural effusion

DOID EFO Endpoint Browser PheWeb

J10_PLEUREFFUSION

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J90, J91*
  • Hospital discharge: ICD-9 — 5111
  • Hospital discharge: ICD-8 — 511[1-2]
  • Cause of death: ICD-10 — J90, J91*
  • Cause of death: ICD-9 — 5111
  • Cause of death: ICD-8 — 511[1-2]

2 out of 7 registries used, show all original rules.

5662

4. Check minimum number of events

None

5662

5. Include endpoints

None

5662

6. Filter based on genotype QC (FinnGen only)

5468

Control definitions (FinnGen only)

Control exclude J10_PLEURA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 49386 19428 29194
Only index persons 36664 14739 21925
Unadjusted period prevalence (%)
Whole population 0.71 0.56 0.82
Only index persons 0.72 0.54 0.84
Median age at first event (years)
Whole population 69.96 71.18 69.13
Only index persons 69.58 70.70 68.83

-FinnGen-

Key figures

All Female Male
Number of individuals 5468 1845 3623
Unadjusted period prevalence (%) 1.45 0.72 1.82
Median age at first event (years) 68.85 65.62 70.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint J10_PLEUREFFUSION and mortality.

Females

Parameter HR [95% CI] p-value
J10_PLEUREFFUSION 4.638 [4.08, 5.27] < 0.001
Birth year 0.997 [0.99, 1.01] 0.508

During the follow-up period (1.1.1998 — 31.12.2019), 9071 out of 14473 females with J10_PLEUREFFUSION died.

Males

Parameter HR [95% CI] p-value
J10_PLEUREFFUSION 3.657 [3.22, 4.15] < 0.001
Birth year 0.99 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 13181 out of 21590 males with J10_PLEUREFFUSION died.

Mortality risk

Mortality risk for people of age

years, who have J10_PLEUREFFUSION.

N-year risk Females Males
1 0.516% 0.574%
5 2.675% 3.896%
10 6.238% 9.99%
15 13.027% 18.751%
20 21.6% 29.907%

Relationships between endpoints

↥

Index endpoint: J10_PLEUREFFUSION – Pleural effusion

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data