No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3371 |
4. Check minimum number of eventsNone |
3371 |
5. Include endpointsNone |
3371 |
6. Filter based on genotype QC (FinnGen only) |
3300 |
Control definitions (FinnGen only)
Control exclude
J10_PLEURA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J90-J94
Name in latin
Lamellae pleurae
Similar endpoints
↥List of similar endpoints to
Pleural plaque
based on the number of shared cases.
Similar with more cases:
- Other diseases of pleura
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
- ILD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22511 | 3209 | 19103 |
| Only index persons | 19742 | 2946 | 16796 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.09 | 0.53 |
| Only index persons | 0.56 | 0.11 | 0.64 |
| Median age at first event (years) | |||
| Whole population | 70.41 | 72.57 | 70.00 |
| Only index persons | 69.71 | 72.31 | 69.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3300 | 340 | 2960 |
| Unadjusted period prevalence (%) | 1.35 | 0.13 | 1.49 |
| Median age at first event (years) | 69.70 | 68.83 | 69.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_PLEURPLAGUE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PLEURPLAGUE | 1.23 [1.1, 1.37] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.658 |
During the follow-up period (1.1.1998 — 31.12.2019), 1033 out of 2963 females with J10_PLEURPLAGUE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PLEURPLAGUE | 1.37 [1.26, 1.49] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 7086 out of 17328 males with J10_PLEURPLAGUE died.
Mortality risk
Mortality risk for people of age
years, who have J10_PLEURPLAGUE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.227% |
| 5 | 0.715% | 1.345% |
| 10 | 1.869% | 3.572% |
| 15 | 3.924% | 6.586% |
| 20 | 7.039% | 11.352% |
Relationships between endpoints
↥Index endpoint: J10_PLEURPLAGUE – Pleural plaque
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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