Pneumothorax

J10_PNEUMOTHORAX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J93
  • Hospital discharge: ICD-9 512
  • Hospital discharge: ICD-8 51299
  • Cause of death: ICD-10 J93
  • Cause of death: ICD-9 512
  • Cause of death: ICD-8 51299

2 out of 7 registries used, show all original rules.

2504

4. Check minimum number of events

None

2504

5. Include endpoints

None

2504

6. Filter based on genotype QC (FinnGen only)

2416

Control definitions (FinnGen only)

Control exclude J10_PLEURA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J90-J94
Name in latin Pneumothorax

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 22531 5868 16399
Only index persons 17810 4882 12928
Unadjusted period prevalence (%)
Whole population 0.38 0.17 0.46
Only index persons 0.41 0.18 0.49
Median age at first event (years)
Whole population 50.37 56.14 48.09
Only index persons 43.39 52.37 40.00

-FinnGen-

Key figures

All Female Male
Number of individuals 2416 689 1727
Unadjusted period prevalence (%) 0.70 0.27 0.87
Median age at first event (years) 57.97 51.11 60.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_PNEUMOTHORAX and mortality.

Females

Parameter HR [95% CI] p-value
J10_PNEUMOTHORAX 3.635 [3.02, 4.38] < 0.001
Birth year 0.995 [0.99, 1.0] 0.272

During the follow-up period (1.1.1998 — 31.12.2019), 1318 out of 3535 females with J10_PNEUMOTHORAX died.

Males

Parameter HR [95% CI] p-value
J10_PNEUMOTHORAX 3.073 [2.67, 3.54] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 3115 out of 8847 males with J10_PNEUMOTHORAX died.

Mortality risk

Mortality risk for people of age

years, who have J10_PNEUMOTHORAX.

N-year risk Females Males
1 0.378% 0.728%
5 2.178% 3.226%
10 5.309% 8.486%
15 9.927% 15.785%
20 16.779% 25.869%

Relationships between endpoints

Index endpoint: J10_PNEUMOTHORAX – Pneumothorax

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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